In my opinion I would go with the fish being treated separately and leaving your main tank alone for at least 6 weeks. Doing hypo in a smaller tnak would be alot easier than doing it in a 150 gallon tank! And then theres corals, inverts and other creatures that you might have in there.
Just my 2 cents, looking for the easiest solution for ya.
180g Reef - 60g Rimless Reef -90G FOWLR- 125g Malawi Cichlids- 40b REEF- 34g Fresh Planted-working on- 20L FOWLR- working on
I have a mix of many different saltwater fish amongst my tanks, but I love my Tangs most of all.