I wouldn't. That sand will still have cyano
on it. Just because you can't see it doesn't mean it's not there. The reality is that most tanks have cyano
. The key is to figure out why it is flourishing. The major first step is eliminating nitrates. Also increase your flow over your sand bed. When I was brand new to the hobby I had to cut my feeding and increased my water changes two fold for a month to eradicate the visual slime. This will be a patience game. But if you do it right this time you will be better off down the road.
Also check out reef cleaners website. They have some interesting insight into clean up crews that they say will help with cyano
(I believe they mean more of a preventative than eradication) may be a good start