In the wild neons are a natural food source for Altum angels. Unless you get wild caught angels or very large adult ones you shouldn't have problems. If you get very small angels with a body since of a quarter or smaller and raise them with neons (try not to get tiny ones like the size of many livebearer fry) there are usually no problems. I've been keeping angels since the 70's and they are still my favorite fish. I currently have 9 breeding angels (3 pairs and 1 trio) in a heavily planted 220g tank. In a 45g I wouldn't do more than 2. When you get small ones there is no way to tell sex. Angels mature at 8 months of age. Angels like most cichlids tend to have individual temperaments so until they mature you really don't know how they will be. I've had males in tanks and females in tanks and I've had females that were as aggressive as males and males as laid back as can be. I've found mature, old males are the ones that can turn quite ill tempered but that is not the norm. I've also had 2 females in a tank and had them spawn (obviously eggs weren't fertile). My angels are always in community tanks and spawn and in all the years I've kept them a spawning pair have never killed another fish. They will drive other fish from the area but don't chase them down and kill them. If you provide a large leaf plant such as an amazon sword in the tank this often makes a great site for claiming, and if planted at one end of the tank, can keep the angel/s very happy.