I just made one out of 1/4" Plexiglass (another brand of acrylic). I used Weldon #3 and it worked great. I didn't even need any silicone to seal. It depends on how smooth your cuts are. I used a table saw with a blade designed for Melamine and just went real slow. After the cuts, you need to smooth out the edges with a razor blade to get the burrs off. I also used the original edges of the sheet for my important joints. If you do not have the equipment to cut it, most acrylic stores will do the cuts for you.
What size fuge are you building?
What thickness of acrylic are you using?