I believe it would be a bit overkill. It may produce too much of a current for the fish and I'm not sure if they are adjustable for the flow. A better bet would be the emp280 or aquaclear150 or 200
80 gallon FW
:3 clown loaches, 2 angels, bloodfin tetras and 1 albino BN pleco,1 Farlowella.
46 gallon FW
: kuhli loaches, otos, black neon and black phantom tetras, 3 pitbull plecos.
50 gallon SW
: 1 green spotted puffer