I'm not a fan of Biowheels. They create extra noise and I do not see an advantage to them.
The reason why I recommend canisters instead of hobs for larger tanks is that they are more efficient. They are easy to maintain (at least my Cascade is, it's simple to take apart and put back together), are hidden from view, and give more circulation. HOBs just drop water down. Canisters can be set to push current.
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