King Fisher
Aquarium Advice Addict
You will have to quarantine the pleco. Do daily water changes. See if he'll even eat first. If not he's going to be hard to save. If he's losing slime coat I imagine he may have some sort of fungus. Pics would help. A good fungal antibiotic could be used to see if it helps. You seem to have quite a bit of additives. I can see the charcoal for clearing up the water and a dechlorinator but outside of that I don't get why you need anymore on a cycled tank.