You can do as many
wc's as you want/need as long as you do the following
1. Match the temp to +- 2 degrees of your tank
2. Match salinity exactly ( using a refractometer not a swing arm hydrometer)
3. Match your trace element levels (can be higher than what's in your tank, and this is not as important as the first 2)
4. Thoroughly mix the saltwater (I mix for ~24 hrs)
Edit: know that 2 50%
wc's will not lower nitrates (or whatever) all the way. If you had 100ppm nitrates and did 2 50% changes it would drop to 25ppm not 0 (50ppm after the first then to 25 after the second). Hope that helps