Bristle Nose Pleco

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Do you want them to breed? If you do, get one male and 2 females and a cave for them to hide in. You will have babies before you know it. I have a breeding trio in my 55 gal and have successfully spawned and raised literally hundreds of the little guys.
 
Well if you don't want to breed them just leave the babies in there and the jack will eat the babies. 3 in a 55 gal would work no problem.

If you do end up wanting to breed them you can remove them when they become free swimming and they will survive.
 
Yes as long as you have caves for them. Jacks can be nasty as I am sure you know, the pleco's will need places to hide.
 
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