My personal experience is that sand can be very messy and hard to clean, I originaly had sand and never had clear water, as soon as my water was clear i would move someting or perform a pwc and again the tank would appear very cloudy again. you may want to add some sand as it will be a good home for your good bacteria but I dont think its neccesary although I do see a handful in every tank in some fish stores.
If you want sand only you will need to take everything out including fish and one you put the sand in wait a day or two for the sand to settle before adding any fish.
Make sure you wash both sand and gravel very well before you introduce it to your tank, also if you buy sand make sure its aquarium sand. Just to add I have 3 aquariums and I dont use sand in any of them, but its self preference, but gravel is certainly easier to clean imo.