As there different types of skimmers you need to find out what yoru manufacturer recommends.
I do a total clean on my skimmer once a year. That means removing it from the sump and taking it apart. I soak what I can overnight in white vingar to remove/soften deposits, then cleain the part under running tap water with a soft brush. The parts then go into a bucket of RO
water with a small ph for a few hours. Then into a 2nd bucket of RO
water overnight before being put back together.
Weekly maintenace is just removing the colection cup (sometimes mor than weekly), dumping it and cleaning it. About every other month I need to clean the air feed of deposits, so that part comes off and gets cleaned.
The initial break in period is due to the oils used in the manufacturing process that coat the plastic. It takes a few weeks for skimmer to remove those. I have heard os people using the white vinegar soak on a new skimmer to remove those oils first. Once tehy are gone though the skimmer is back to peak efficiency within hours of being put back in service.