It's up to you.
Gravel is easier to maintain and less likely to get sucked out when you do a water change, or get pulled into your filtration causing excess wear and tear or jamming stuff up.
Sand is better for bottom feeding fish as its usually softer on their barbels, and it's easier to see poop than on gravel as a visual clue as to if you need to clean things. Toxic gasses can also build up in sand substrate which can kill fish if it gets released into the water. So periodically disturbing the sand will stop these pockets developing.
Half and half will mix unless you put some kind of physical barrier between them. But its not like the sand will spread from the left hand side to the right hand side. It will just mix at the boundary and you still have sand one side, gravel the other, and a blurry neutral zone where they meet.