Well actually since I posted, I have changed my mind....
I had chopped up 1 tile and used as decor for a 20L. I had it running empty with a filter for 2 weeks and I tested the ammonia and it was sky high. I did a 100% change, thinking it was just because the tank wasn't cycled and transferred my fish and filter from a 10gal. Then I started losing fish after fish, and did a huge water change and removed the slate. Thankfully the rest of fish are fine, but I'm not using the slate again.
It might just be the one piece, so I'd place the slate in a bucket of water, and test the tap water(All values), then test after 24 hours and a week later.