A standard 75g is ~48" long x 18" wide x 20" tall, and that is with 1/4" glass. So i don't see why special precautions need to be in place...just be careful and take your time.
The silicone will help hold the glass in place, as well as the upper and lower framing, but >1/4" glass can handle the weight. you could always add support to the stand as well if you are concerned.
75g FW Planted Community; 55g African Cichlid
29g Biocube SW Reef;12g AP Mantis Shrimp/Brittle Star
2 Cats, 2 Dogs, 5 Turtles