Could you house a porcupine puffer with a lionfish or is that a BIG No No?

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Generally no they do not mix well . It all depends on the temperament of the puffer . Most kill all tank mates. If you try you must have a very big tank and have a back up plan. My porc and zebra have been together for 6 months with no issues so far. It is risky though.
 
Yep that's a possibility when you keep a lion with all fish. Mine will actually put his back spines down when chop swims close so he doesn't get him .
 
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