Matt68005
Aquarium Advice Addict
Sorry to hear your woes. With a tank with substrate, i think it would be hard to get all the worms and eggs/larve out of the substrate. Sounds like they didn't like that last dose. IT is possible to overdose fish medicine, and you got to take into account how the medicine makes them feel, like physically, like you don't want to torture a fish that is sick in the first place. I would personally take it down then, stearlize everything and get some diffrent guppies or fish.