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I have a Fluval 406 on a 55 and it is a good size. Plenty of room for filter media and good flow. I'm not a fan of HOB filters, at first had a Wisper EX70 on the 55 while waiting for my canister and I didn't like the results. There is no way to add different of extra filter media and replacing pads can get expensive. I'd do a canister of some type.