Not really, just different.
Detritus will just sit on the surface, rather than get into the voids between pieces of gravel. So its easier to see any uneaten food, or poop that needs cleaning up when you do your tank maintenance. You could even spot clean your substrate daily with a turkey baster and keep your substrate spotless.
Sand can get drawn into syphons, so no gravel vacuuming otherwise you will just suck out all your substrate. Just syphon out over the surface so you draw out any detritus from the surface of the sand. Sand can also get into your filtration and wear out the mechanics, so keep your filter intake higher than a gravel substrate to ensure sand doesnt get pulled in.
Sand has a tendancy to compact, and also trap built up gas that can get released and may be toxic to fish. Im not sure if the gas thing is real or a myth to be honest. Ive never actually seen or read anyone that has had it happen and kill fish. Its probably something that has happened to someone at some point, but it seems unlikely to be harmful to me. Someone will now tell us its happened to them. Given the compaction and gas possibilities, sand is commonly agitated to prevent these (i use an afro comb). Or keep fish that like to stir up the sand (corys and loaches) or snails that like to burrow (malaysian trumpet snails). If you go MTS they can multiply and become a pest if your tank is overfed though.
Fish that like to burrow in and forage on the substrate will benefit from sand. Fish that occupy the upper parts of your tank couldnt care less whether its sand or gravel.