Quick answer is yes, but the longer answer is maybe good idea maybe not.
One thing to see if there is a missing or broken brace on the tank, found at the top where the trim comes together from the front and the back, and where one might sit a glass top.
Usually on a 4' tank there will be one in the center, but some have an extra set in between, at, say the 1' area between the center and the end.
If you have braces and they appear to be secure and after you learn how to silicone a tank, I would watch a large number of videos on "how to".
If there is a cracked or broken trim/ braces then I would not chance in in my house. (You could do a patio tank though.) You can also check with the manufacturer about ordering a new trim.
Then it really is pretty simple. Check out all the seams and I would just make sure to get the area completely cleaned off of one side at a time and do the complete section including 6-8" along the bottom front and side, and you might as well do the top as well.
The reason is so that you don't end up with a stopping point that doesn't connect well at the bottom corner, and causes a flood. I would do all the seams over. king of diy has a video if I remember. Outside bead/seam and an inside seam so they combine and become one strong seam on the sides.
Make sure to pick up the appropriate kind and none with mildew resistent or fungicide.
I would only use Aquarium silicone if it were me. 75G of water on the floor would be a very bad thing.
The largest tank I ever resealed was a 37G. Not as big as yours. Others input and experience with large sized tanks, and watching the videos to get a consensus of great ideas and methods should be a valuable tool as well.
If you reseal, share some pics!