I definitely agree with Rich. I've noticed during the time that I've been here that the people with the most problems (sick fish, etc) tend to lack in water changes. I do no less than 50% weekly in all my tanks. pH shock is something that's hugely overrated in aquaria. Fish are much more resilient to changes in temp, water chemistry, etc, than a lot of people give them credit for IMO. As long as your tap water is relatively close to your tank, in terms of chemistry, I dont see you having any problems.
And, it's true that two smaller water changes don't = one bigger water change. Let me see if I can explain:
If you have a 100g tank with 10ppm nitrate for instance. A 50% water change (50g) will reduce the nitrate to 5ppm. If you do a 25% PWC, the nitrate will be reduced to 7.5ppm. Another 25% water change will only bring you down to 5.625ppm. Not a huge difference, but if you were talking about levels on a much larger scale, then you'd see a noticeable difference.