Can you give is a little more info? What size tank? Does it have fish? If so, what? How long have you had the fish? What test kit are you using? Did you ever have an ammonia reading?
If you have fish I suspect that you're entering the nitrite phase, which is as dangerous to fish as ammonia so you'll need to do water changes any time ammonia or nitrite get over .25 to keep it down, but without more info I'm just guessing.