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Bio balls are never meant to be replaced. Is this what you are talking about? Those little plastic or ceramic balls?
Are you going to be using the canister as your primary biological filter, or are you using LR? If you are using LR, then the only thing I would put in the canister is carbon.
this stuff is not bio balls. It's sintered glass. If you choose to run a canister filter, and have only fish, you should be OK... You should remove the media and wash it out in clean salt water every month or so to avoid buildup of gunk which would otherwise cause trouble.