Only do brackish if you are doing only species that naturally live in brackish waters. Yes, some can be acclimated into it but true freshwater or saltwater fish won't be as happy and healthy in brackish water. Plecos do not like salt. There are lots of cool brackish water fish, but you would have to cater to their needs and avoid all true freshwater fish. Also, you need marine salt to do a brackish tank, and it can get expensive mixing the water up for weekly pwc's with the marine salt. I know, my 30 gallon is a brackish tank for puffers. My tank is higher brackish than you would need to go if you were keeping guppies, but I still use a few cups of salt every week for a 30.