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Are you planning to have plants with CO2 injection? A wet/dry probably provides the best pure filtration, but it has down sides to it if you're trying to keep things like CO2 in solution.
For 150 gal tank you would need more than HOB's. I run a fluval 404 and FX5 on mine. And they still get very dirty. Esp if you are going to stock with a messy fish like cichlids for example.