Pardon??? Popeye is caused the the majority of the time from bad water conditions.
Popeye in fish is most frequently caused by continual exposure to chronically poor (rather than acutely lethal) water conditions. Popeye is consequently most common in aquariums that are overcrowded or receive infrequent water changes. Not surprisingly, popeye is most often seen in aquariums where messy fish are kept in unhygienic conditions.
I run a tight ship and never had Popeye cause my waters always pristine hope someone else can help you as you have a bit of a chip.
Yes it's worth treating or your fish will die.