If it is a common pleco, I've always heard that they do not particularily take kindly to their own kind. If he's been moved to a smaller tank, he may just be restless or searching for food because the tank isn't as built up with algea and such.
I've recently had to move an 8in common pleco from a 75 gallon to a 20L temporary tank while cleaning it (See the unhealthy fish forum...an on going battle against ammonia). He was extremely restless for a while, searching the sides of the tank.
After a few hours he finally settled down. I knew there was nothing in the tank for him to eat so I dropped a small slice of cucumber in for him to eat. He latched on to it and has behaved more normally.
What size tanks are you talking about? If you're worried about fish getting big, the pleco might be the one you really need to worry about.