I don't use Reef Plus. I actually use Kent Marine's Zoe for vitamin supplementation. I am very happy with that. Doesn't cause the skimmer to go crazy either like a lot of other vitamins do.
One of the things I see with Reef Plus that may cause problems is dumping all those minerals into the water. As long as you perform regular water changes (once every or every other week) you don't need to worry about any of that stuff.